Authors: Nur Dokuzeylul Gungor, Kagan Gungor
Objective: The aim of this study was to determine the ratio of CRP/albumin (CRP/Alb) and the monocyte/HDL ratio (MHR), new inflammatory markers, in women with gestational diabetes mellitus (GDM) and normal glucose tolerance test (NGT).
Methods: Thirty pregnant women who underwent 50 gram glucose challenge test (GCT) between 24-28 gestational weeks were included the study. If the serum glucose level was above 140 mg/dl on the 50 gram GCT, 100 gram oral glucose tolerance test (OGTT) was applied. Diagnosis of GDM in 20 patients was confirmed if two of the blood glucose test results were above the following levels: fasting serum glucose ≥92 mg/dL and/or 1hour glycemia ≥180 mg/dL and/or 2 hour glycemia ≥153 mg/dL. Ten patients with a result below this value were accepted as NGT. The CRP/Alb and MHR were determined. Correlation between biochemical, demographic parameters, CRP/Alb ratio and MHR in GDM and NGT groups were analyzed.
Results: No significant difference was found between GDM and NGT groups interms of maternal CRP/Alb ratio and MHR. Fasting insulin, fasting glucose, and 2 hour glucose levels as well as HOMA-IR of patients with GDM were higher than those in the NGT group. Maternal CRP/Alb ratio was positively and significantly correlated with HOMA-IR (r:0.52, p<.001), fasting insulin (r:0.71, p<.002) and BMI (r:0.76, p<.01). We found insignificant correlation between MHR, BMI and HOMA-IR. Any association was not found between HOMA-IR, fasting insulin levels, BMI and CRP/Alb, and MHR in NGT group.
Conclusion: Maternal CRP/Alb ratio correlates with HOMA-IR and BMI of women with GDM.
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