Authors: Prashant Khemariya, Ankit Agrawal, Elango Minnoor.
The term “Ayurveda” combines the Sanskrit words ayur (life) and veda (science or knowledge). It is one of the traditional medicinal systems, with an established history of many centuries. Indian herbs, which are widely used in the preparation of Ayurvedic medicines in the form of Kadha to control various respiratory disorders such as, cough, cold and flu. In a traditional Kadha (decoction) preparation, the entire process is done manually Such as boiling, filtering and mixing of medicinal herbs and the aim of this research work was to skip all such manually process. The oral route of drug administration is most extensively used due to the obvious ease of administration. Dispersible tablets are a vital tool in keeping our children and elderly population healthy. Their ease of use and accurate dosing allow higher patient compliance and more reliable therapeutic effects. Medicinal plants and parts as like Tulsi (Rama-Tulsi) (Ocimum Sanctum Linn, family Lamiaceae), Ginger (Zingiber officinale, family Zingiberaceae), Clove (Syzygium aromaticum, family myrtaceae) and Turmeric (Curcuma longa, family Zingiberaceae) were used as a model drug. Phytochemicals present in these herbs, which have significant potential to heal cold and cough. The phytochemicals present in these herbs possess significant anti-inflammatory property. In order to determine the most effective type and optimal amount of superdisintegrants for dispersible tablets different formulation were evaluated. Wet granulation and direct compression methods were tried to develop dispersible tablet. Due to higher moisture in the granules the wet granulation method was not carried out further in the study and direct compress method was selected. Prepared tablets were tested for Appearance, Weight variation, Thickness, Friability (%), Hardness (kg/cm2 ), Disintegration time and IR spectroscopic analysis and finally for six months of stability studies at room temperature, 30ºC/60% RH and at 45ºC/75% RH. Sodium Starch Glycolate was superior to the other disintegrants and the non-fractionated granulation gave adequate dispersion. The ideal concentration was 1.33 % Sodium Starch Glycolate was used for the dispersible tablets
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