Authors: Kurnia Penta Seputra, Agung Adhitya, Taufiq Nur Budaya, Besut Daryanto.
Introduction: Malignancy as one of unresolved health problems globally is shown to be the second highest cause of death in the world. One of the most common cancer in Indonesia is the urothelial cancer, this type of cancer placed eighth among all cancer with bladder cancer as the second highest urothelial cancer type. At this point, there is no routine effective bladder cancer screening test. Urine cytology examination of a urine specimen is a simple, safe, and inexpensive method but highly dependent on the skill of the examiner. The aim of the present study was to test the value of urinary cytology in the diagnosis of bladder cancer at Dr. Saiful Anwar General Hospital Malang.
Methods: 216 patients diagnosed with bladder tumor by histopathological urinary cytology test. The positive cytology categories by papanicolaou classification. The efficacy of urine cytology for detection bladder tumor was determined by calculating its sensitivity, specificity, positive predictive value (PPV), Negative predictive value (NPV) and Prevalence of disease.
Results: From 216 patients, 113 patients (52,3%) had bladder tumor, with the value of sensitivity 51.31% and specificity 88.15%. The positive predictive value was 81.88%, whereas the negative predictive value was 64.36%, with the prevalence of disease 50.59%.
Conclusion: Urine cytology has high specificity with intermediate sensitivity. The highest sensitivity of urine cytology when used to diagnosed muscle invasive with metastatic bladder cancer. Urine cytology should always be confirmed histologically before definitive therapy.
View/Download pdf