Authors: Cruz-Rodriguez L, Dilsiz N, Barea R, Ziarati P, Hochwimmer B, Zayas Tamayo A, Lambert Brown D.
Exosomes are a novel horizon in modern therapy and open exciting new opportunities for advanced drug transport and targeted release. Exosomes are biological nanoparticles with dimensions ranging from 30 to 100 nm and are generated by all cell types in the human body. Exosomes-which are extracellular vesicles that function in intercellular communication-may play a key role in the dissemination of vaccine as well as host-derived molecules during cancer disease. We highlight the composition and function of exosomes produced during cancer disease in our work, how these vesicles could function as carriers of the RNA-peptide molecule. Finally, according to the algorithms CRUZ RODRIGUEZ (CR) we are proposing various methods to develop a novel vaccine against breast, ovarian, and lung cancers. Therefore, six RNA-peptides from our previous study were chosen based on the potential of inducing strong fusion stability (FS=58.50 cruz) and exosome affinity (EA=59.80 ro), Biological Action (BA= 1.0223 ro/cruz). This result may lead to the development of promising new therapeutic approaches in cancer management by using exosome-mediated miRNA-peptide vaccine therapy. Due to, according to the algorithm CR the Optimal Biological Action (OBA) value for antitumoral RNA-peptide with Exosome as carrier are: 0.8 < OBA < 1.3. These results suggest that the designed vaccine can elicit specific immune responses against three types of cancer; however, these results need experimental studies to confirm the efficacy and safety profile of the proposed vaccine structure.
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