Authors: Jerome H. Check, Diane Check, Joanne R. liss.
Purpose: To evaluate the efficacy of treatment with dextroamphetamine sulfate of refractory weight loss by dieting related to fluid retention secondary to the increased cellular permeability syndrome over a 5-year period.
Methods: Women were excluded for pathological causes of fluid retention, e.g., hypothyroidism, Cushing’s syndrome, heart failure, or renal or hepatic disease. Dextroamphetamine sulfate was initiated at 15mg extended-release capsules with the option of increasing the dosage as necessary up to a maximum of 60mg a day.
Results: Forty-four percent of the women lost at least 10% of their initial body weight in 6 months and 42% still lost at least 10% by 5 years. For the first 4 years there were about 15% who lost about 15% of their initial body weight. At 5 years only 7% failed to have any weight reduction compared to their initial weight.
Conclusion: The amphetamines seemed to cause weight reduction by diminishing fluid retention rather than causing caloric reduction.
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