Authors: Russo A.J, Albert Mensah, Judith Bowman, Barbara Garcia, Katherine Padgett, James Lukasik.
Interleukin (IL) receptor expression has been shown to increase significantly during maternal immune activation. It has been suggested that dysfunctional Interleukin activity is associated with cortical dysplasia and ASD-like behaviors. We measured the concentration of 30 cell receptors, including 5 Interleukin receptors (IL-1R, IL-2R, IL-10R, IL-17R and IL-21R) from mothers with at least one autistic child and neurotypical, gender and age similar controls, using immune-arrays. Of the 5 Interleukin receptors, 4 (IL-1R, IL-10R, IL-17R and IL-21R) had concentrations significantly higher in mothers of autistic children, when compared to neurotypical controls.
View/Download pdf