The increasing prevalence of non-communicable diseases (NCDs) in Nigeria, like many other developing countries, has become worrisome. With the pre-existing health burden due to malnutrition, the challenges of low productivity, poverty, reduced economic growth and development are exacerbated. It is also a significant threat to the attainment of the Sustainable Development Goals (SDGs) in Nigeria. Several risk factors have been associated with this increased burden, including genetic, environmental, and behavioural. The rise in urbanization and globalization has undoubtedly had a significant influence on consumer food and drink preferences and choices. Many of the risk factors are preventable with changes in diet, lifestyle, alcohol, and drug use, among other measures. However, to prevent the growing occurrence of NCDs in Nigeria, critical and relevant stakeholders must work together with a definite agenda and concerted efforts to combat this challenge. This paper examines the roles of stakeholders, including global and national governments, industry, and consumers, and advocates a holistic and genuine commitment to measures that will fast-track the implementation of various recommendations such as WHO SHAKE and use of Front of Pack Labelling.